Hydrogels based on Boronic Esters and Diols Interactions: New formulations and Applications

告题目: Hydrogels based on Boronic Esters and Diols Interactions: New formulations and Applications

报告人:Prof. Dr. Ravin NarainUniversity of Alberta



Hydrogels are crosslinked polymeric networks that can be designed to mimic physical properties of human tissues. Though the fundamental nature of hydrogels offers great potential for various biomedical applications, hydrogels prepared from conventional approaches with covalent interactions seemed unable to fulfil some of the requirements of future medicine. Therefore, in recent years, more attention has focused on stimuli-responsive and self-healing hydrogel-based materials. The self-healing ability can offer better performance of the hydrogels, while the sensitivity to internal/external stimuli, such as temperature, pH, light and biomolecules enables the hydrogels can be exploited to create the necessary environment for cell or tissue growth within the scaffold or be used for the controlled release of therapeutic agents. Usually, non-covalent interactions (e.g. host-guest complexations and hydrogen bonding) and dynamic covalent chemistry (e.g. Schiff base, disulfide, hydrazone, Diels-Alder reaction, and boronic ester) are the most common ways to prepare self-healing hydrogels, and the latter, appears more convenient to accomplish the simultaneous stimuli-responsiveness via dissociation of the dynamic covalent bonds. In this talk, I will highlight the easy fabrication of self-healing and responsive hydrogels using polymer entities containing boronic esters with various polymers containing diols to generate materials with tunable properties.



(1)Y. Chen, W. Wang, D. Wu, M. Nagao, D. G. Hall, T. Thundat, and R. Narain, Injectable Self-Healing Zwitterionic Hydrogels Based on Dynamic Benzoxaborole–Sugar Interactions with Tunable Mechanical Properties, Biomacromolecules(2018),19, 596–605

(2)Y. Chen, D. Diaz-Dussan, D. Wu, W. Wang, Y.-Y. Peng, A. B. Asha, D. G. Hall, K. Ishihara, R. Narain, Bioinspired Self-Healing Hydrogel Based on Benzoxaborole-Catechol Dynamic Covalent Chemistry for 3D Cell Encapsulation, ACS Macro Letters (2018), 7 (8), pp 904–908

报告人简介:Ravin Narain, PhD, P.Eng, is a Full Professor and an established researcher in the Department of Chemical and Materials Engineering at the University of Alberta, Edmonton, Alberta, Canada. He has made original and innovative contributions to the design, fabrication, characterization of novel polymers and nanomaterials for a wide range of applications. Dr. Narain’s research examines biomaterials, nanomedicine and regenerative medicine, with an emphasis on developing new biomaterials for drug and gene delivery applications. In particular, he has made significant contributions in the area of glycopolymers and glyco-nanomaterials for a range of applications primarily for biomedical uses. His laboratory mainly focuses on the reversible addition-fragmentation chain transfer process for the synthesis of well-defined polymers. He has published over 130 articles in peer-reviewed and high impact journals and is the editor of 5 books namely Engineered Carbohydrate-Based Materials for Biomedical Applications (Wiley), Chemistry of Bioconjugates (Wiley), Glycopolymers: Synthesis and Applications (Smithers & Rapra), and Polymers and Nanomaterials for Gene Therapy (Woodhead Publishing & Elsevier Inc.). He is currently on the Advisory Board for Polymer Chemistry (RSC) and is the Editor for three special issues for Polymers (MDPI): Polymers and Nanogels for Gene Therapy; Responsive Polymers for Drug Delivery, Imaging and Theranostic Functions; Advanced Polymers for Engineering Applications.